Research shows that the brains of people living in cities operate differently from those in rural areas. Scientists found that two regions of the brain involved in the regulation of emotion and anxiety become overactive in city-dwellers when they are stressed.
Previous research has shown that people living in cities have a 21% increased risk of anxiety disorders and a 39% increased risk of mood disorders. In addition, the incidence of schizophrenia is twice as high in those born and brought up in cities. Urban living is also associated with increased risk for chronic disorders, a more demanding and stressful social environment and greater social disparities. The biological components of this complex landscape of risk and protective factors remain largely uncharacterised."